When we first see Omnipotous in space, he devours the planet of The Little Prince, the title character in the famous book by Antoine De Saint Exupury.
Yank (the monkey from "The Tick VS Pineapple Pokopo") is present in the control room at NASA. Apparently, he's still employed with the space program, despite having already lost his genius intelligence by the end of his first episode.
Mayor: Arthur, you may think that nothing can fill the void left in your life by the Tick's untimely departure from this world, but the city council has also commissioned for you this deluxe assortment of cheeses in a handcrafted wicker basket… You better refrigerate that after you open it.
Mayor: Too soon the Tick was plucked from our mitts and hurled screaming into the Heavens. What a guy. And to commemorate his great sacrifice the city council has commissioned this beautiful fiberglass resin statue to stand forever in his honor.
Die Fledermaus: The head is way to big.
The Tick: (to Omnipitous) Man, for a big guy, your feet are freaky small!
Arthur: Die Fledermaus, we've been at this for a week now and all we do is look at fashion magazines and hang out at the diner. Don't you ever fight crime?
The Tick: I've been the janitor to the apocalypse for two long months, Arthur, and it's a comin' this way!
The Tick: This is one small step for the Tick and one giant step for a... uh, say a little bug or maybe some guy that's been shrunk to the size of a penny.
According to TVshowsonDVD.com this episode will not be on the season 2 set. Because Omnipotus is legally too close to the Marvel Comics character Galactus.
Omnipotus leaves a bite-mark in the moon which is seen for the rest of the series.
Despite watching the news about the Tick in space with the other prisoners, Chairface Chippendale has no lines.
After the Human Bullet flies into the wall with Arthur (as his temporary sidekick), Bullet says "I'm OK, you're OK." I'm OK, you're OK is the title of a very famous pop psychology book by Thomas A. Harris, MD.
Omnipotus is a spoof on the Fantastic Four's villain, Galactus, who pretty much does the same thing. Also, Galactus chose The Silver Surfer as his herald, which was spoofed by the Tick being Omnipotus' janitor.