Mayor Lockwood was NOT a werewolf. as Katherine said, the werewolf gene runs in the Lockwood family not that they're all wolves. And we don't know how George Lockwood died. For all we know Stefan could have killed him in 1864 or he could have killed himself because he was tired of transforming every month. My point is we have no proof or any real clues that let us know that werewolves live longer than an average human.
Mayor Lockwood was a definitely a werewolf hence why his son became one, he may not have shapeshifted under the full moon like his brother Mason, but the very reason he died it's because he responded to the Gilbert device just like a werewolf would (See Jonas Martin's spell on "Crying Wolf"). IMO, all this speculation about "werewolves Originals" has no basis whatsoever so lets get back to how many plot points "The Last Dance" rehashes from the first dance episode from last season.