The Virginian and Trampas arrive at the Medicine Bow saloon just as young Johnny Younce stumbles out. Johnny looks in the window of a tailor shop owned by Jake which contains a sign 'the clothes make a man." Johnny proceeds to break the window and goes on a rampage.
A destitute former Minister, David Henderson (Glenn Corbett), who has had a crisis of faith, comes to Medicine Bow just as a dispute breaks out at a local mine over safety issues. Emmett Ryker entreaties Judge Garth to try and find a solution to the problem. When an accident occurs at the mine David assists in a rescue attempt but hurts his leg. He is taken to Shiloh where Betsy Garth nurses him and they become romantically involved. David's actions gain him the respect of the miners, he becomes their leader, and he calls a strike over the working conditions. Despite an attempt to intimidate the miners by importing scab labour, with Judge Garth's help the owners and miners manage to reach an agreement. David rediscovers his calling and asks Betsy to marry him. They are married at Shiloh Ranch and head off to start a new life at a parish David has been assigned in Pennsylvania.moreless
A shared piece of grazing land causes conflict between a neighboring ranch and Shiloh. The problem becomes exacerbated when a passing stranger saves Trampas after he is knocked out by the neighbor's son. Because of the stranger's good turn to Trampas, he is hired as a handy man by Shiloh. Since the stranger looks like a notorious fast gun, the neighboring rancher's son thinks the Grangers hired him to fight for them in the existing conflict. Is the stranger really the notorious gunfighter, or just a nice, gentle man? The answer unfolds as the story progresses and Trampas and the stranger become close friends.
The Virginian is taken prisoner by armed men determined to have him stand trial for being a hired gun and killer.
Doc Watson and Miss Claire are partners in a mind-reading act. The girl attracts Clay's attention, due to the fact she may be his missing niece.
Trampas arrives in Triste which is nearly deserted. He receives a death threat from an obsessed gunfighter who is dressed all in black and is known as the Executioner. He is determined to force Trampas into a gunfight.
During a cattle drive with Tate, Col. MacKenzie hunts a wolf.
When the Virginian offers Tate's help with fencing on a neighbor's ranch, the owner's underage daughter becomes romantically interested in him.
Colonel Mackenzie accompanies a young woman by train to her uncle's place. During the trip, he insists that the train stop so he can prevent the hanging of an innocent man.
In order to honor the wishes of her late husband, a woman who lives in a commune with her daughter seeks the Virginian's help.
The Virginian believes in the innocence of a new ranch hand who just happens to be the prime suspect in a murder.
Trampas helps a young woman find her mother whom she believes to be the cause of her father's distress. But the mother is involved with a criminal boyfriend.
Trouble starts when ex-convict Frank Hollis returns to Shiloh. He blames Trampas and Clay for his father's crippled condition, who worked at Shiloh as a wrangler.
Jim is in North Dakota to purchase ponies when he tangles with a pair of sharp operators after his $4000 bank roll.
Colonel MacKenzie helps a young woman who is said to have gone missing on her wedding day.
Facing murder charges, Trampas is represented by a female attorney who is a stickler for procedure.
During a stopover in a strange town, Trampas is considered to be an outlaw. He is allowed to live until the sheriff gets back. Another man is mistakenly thought to be the sheriff.
A woman is victimized by two men when the Virginian comes to her aid.
Trampas' vacation takes a nightmarish turn when he's jailed in a small town on a trumped-up murder charge.
Tate is on a mission to get medical help for Colonel Mackenzie, who has been badly injured during a cattle drive. But the only available doctor in a nearby town is due to be hanged.
Lucy Hammond and her teenage daughter Marjorie arrive by train in Medicine Bow. Marjorie is enthralled by her first trip west which she imagines to be like the dime novels featuring her hero Deadeye Dick.
While on the trail, Tate runs into a hunting party and its prey.
Two young men and a girl take over the Shiloh ranch and hold the Graingers captive. They are setting up a trap for a close friend of Clay's, Judge Will McMasters.
The Virginian becomes involved in a lawman's obsessive search for two surviving members of a gang.
The Shiloh people unwittingly stir up the past when they shelter the son and white widow of a Shoshone.
Trampas deals with an outlaw family that has kidnapped Colonel MacKenzie in exchange for one of their sons.
Trampas becomes the target of abuse and hatred when he implicates the town doctor in a murder case complicated by scandal.
Adam Randall is hired on as a Shiloh hand despite his being a gunfighter. Despite his being a troublemaker, the Virginian, whose life he saved, and Clay, for unknown reasons, stand behind him.
Tates heads into town hoping to meet an old flame. He becomes involved with a crooked card player.
The accent is on comedy as a proper Southern woman, aided by Trampas and old Luther, goes after robbers who took her dowry.
The Virginian tries to help out an old man whose outlaw son he killed. The dying old man has one last wish, to see his daughter who has lived with the Shoshone for many years, before he dies.
A Comancheros leader captures Colonel MacKenzie and a female reporter.
A story of alienation between a veteran Army officer and his son, a deserter.
The Virginian becomes attracted to Julie Oakes, an Eastern reporter whose mysteriously tragic past may doom their relationship.
A politician's brother fires a warning shot at the Virginian and causes more trouble for others.
Col. MacKenzie deals with American Indian braves out to reclaim their lands by attacking white settlers.
Jim becomes farmhand, midwife and friend to a pregnant teen whose husband is on the lam from the law.
A man signs on to work a cattle drive for the Shiloh ranch putting the other hands in danger. He is a fugitive Indian caught between the white world and his Kiowa roots. Things get heated when they come to a small, bigoted town.
Trampas becomes involved in a bittersweet romance.
A farmer who has been poor his entire life suddenly comes into a lot of money. He goes on a spending spree giving large parties, buying luxury items, and a ranch hand more than willing to help him spend it.
Clay's bid for territorial representative nets him a lesson in politics.
A Shoshone Indian girl return from the East after receiving an education. She is unsure if she want to rejoin her tribe and seeks advice and help from the Graingers. Her tribe is facing threats from a land-greedy cattleman.
Colonel MacKenzie's friend has been killed in town after a fight with a young man who feels his sister's reputation was ruined.
Trampas is asked by his friend Pick to be best man at Pick's wedding in San Ysidro. But Pick has not asked the girl yet; and complicating matters is the fact that she's been proposed to by another beau.
The Virginian deals with a widow's trouble-making young son.
The Graingers become stand-in parents for a boy running away from an orphanage.
A dishonest gambler skips out when a riverboat is taken over by a group of armed men.
When the wife of a prominent Medicine Bow business man arrives, smoldering jealousies quickly rise to the top.
On a train to Cheyenne, Clay, Elizabeth and Jim become involved in a fellow traveler's efforts to escape a vengeful family.
The Shiloh ranch is burned down after Clay joins with his fellow ranchers to oppose an Eastern combine trying for a land-grab. This leaves Clay with only has one chance for survival of the ranch, get a herd to Denver in record time.
Trampas and fellow stage passengers are stranded at a ferry crossing. They prepare to face an attacker.
A bigoted gambler and his outlaw gang force Trampas and a black recluse into an alliance for survival.
When Elizabeth takes refuge in an abandoned mine during a storm, a cave-in seals her in. Racing against time, the Virginian, Trampas, and the Graingers try to dig her out before her air runs out.