Mulder and Scully investigate the murder of a city official, a crime that doesn't appear to have been committed by human hands. Meanwhile, Scully faces deeply emotional feelings about the child she gave up for adoption.
Mulder and Scully investigate a dead body in the woods, and try to determine whether it was the work of a serial killer, an animal or a mysterious creature seen by eyewitnesses. Meanwhile, a disillusioned Mulder confronts some of his own demons.
When Mulder and Scully try to discover what unseen force may have driven a scientist to commit suicide, they turn up a laboratory where extreme genetic experimentation has bred subjects possessing dangerous powers.
In the Season 10 opener, agents Mulder and Scully return after 13 years to investigate a government conspiracy at the behest of a popular web-TV-show host, who introduces them to a woman who claims she's an alien abductee and shares startling news with them.
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