In the scene where Scully bends down to retrieve the insect from the dead prisoner's facial wound, her surgical mask is around her neck. As she stands back up with the insect in her tweezers, she is wearing the surgical mask.
18:23 As Mulder turns to look at helicopter, as men pull out the gurney, there is a visible camera reflection, just to the right of his left shoulder.
Why would Scully, a trained medical doctor smack in the middle of a prison where an unknown contagion has spread, only put on a mask and gloves when examining the bodies? She should know enough to at least wear a surgical suit.
Why would she irresponsibly slit open a body bag when she knows the person inside is infected with the disease, and she has no idea how the contagion is spread?
Scully: According to the briefing, prisoners escaped by hiding in a laundry cart.
Mulder: I don't think the guards are watching enough prison movies.
Mulder: I thought this was about escaped prisoners.
Scully: It is.
Mulder: Then who are the men in funny suits?
Skinner: Agent Mulder, I'm saying this as a friend. Watch your back. This is just the beginning.
Skinner: You never had a chance, Agent Mulder. For every step you take, they're three steps ahead.
Mulder: Well, what about you? Where do you stand?
Skinner: I stand right on the line that you keep crossing.
Mulder: You can't protect the public by lying to them.
Cigarette-Smoking Man: It's done every day.
925, the address of the prisoner's girlfriend, is the birthdate of Gillian Anderson's daughter, Piper Maru.
The producers debated whether to delay the airdate because of its proximity to the release of the similarly themed movie Outbreak but ultimately decided that the episode stood on its own.
The title of this episode refers to the name of the insect carrying the infection, Faciphaga emasculata. Although this particular insect is fictitious, there are diseases with symptoms which resemble those depicted in this episode, such as myiasis, in which certain species of fly larvae grow under the skin and emerge from abscesses or boils. On the reality side of the story, scientists do hunt through rain forests for plants and insects for pharmaceutical research, like the unfortunate Dr. Torrance.
Young actress Jenny-Lynn Hutcheson appears in this episode in an uncredited bit-part and also appears uncredited in season 4's "Paper Hearts" as the body of Addie Sparks in Mulder's dream. In season 5 she returns again in the more substantial role of Polly Turner in the Stephen King co-written episode "Chinga."
Chris Carter wrote the part of gas station attendant Angelo Garza especially for X-Files Production Assistant Angelo Vacco.