When Mulder calls Scully's hotel to see if she is in her room. The hotel receptionist puts Mulder through to Scully's room where it is only allowed to ring twice before it is disconnected and the receptionist tells Mulder there was no one there. Surely they would wait a while longer for an answer.
After Scully walks away from Eddie in the his apartment and drops her FBI identification, there is a close-up of Eddie's tattoo with no cigarette burn. The next shot when Eddie is putting the phone receiver to his ear, the cigarette burn is clearly visible.
A scene in the bar in which Scully, after she returns from the bathroom, seductively tells Ed that she had just tossed away her panties was removed from the final episode due to being too exaggerated.
In the DVD audio Betty is constantly alternating between left and right channel in stereo. This gives the illusion that Betty is also in the audience's head as well!
When Ed Jerse bangs on the floor in his apartment, the girl downstairs cranks up the stereo, playing the Partridge Family song "Doesn't Somebody Want to be Wanted".
Scully logs on to fbi.lab.rl.fns.gov/forensics to check the poison information. There is nothing at that site currently.
Mulder: I was thinking of getting a NY tattooed on my ass to commemorate the Yankees' World Series victory.
Betty: (Getting angrier) Another woman in my bed?! Burn the sheets. Burn her.. Burn HER!!
Scully: So what makes this place a good place to go when you feeling down
Ed: Ah its kinda.. Everyone here looks like their problems are worse than mine, makes me feel good about myself.
Betty: Go ahead, treat yourself. This girl is a real doll. But beauty is only skin deep baby... I go all the way to the bone.
Mulder: Eeny Meanie, Chilly Beany the spirits are about to speak
Scully: Rocky and Bullwinkle are looking for an opsidasium mine, Boris Boranoff alters a road sign which causes them to walk on to a secret military base. Where they are picked up by a car with no windows and no door locks and there are silent explosions from a compound called hushabum.
Mulder: So you're refusing an assignment based on the adventures of moose and squirrel?
Mulder: (To Scully) Congratulations, For making a personal appearence in the X-files for the second time.. A World record.
Mulder: All this because I . . . because I didn't get you a desk?
Scully: Not everything is about you, Mulder. This is my life.
Mulder: I'm just at that special place and I wanted to share it with you. You know that Elvis bought all the furniture in just 30 minutes?
Mulder: Okay, so we... we'll have them send down another desk and there won't be any room to move around here but we can put them really close together face to face. Maybe we can play some Battleship!
Originally slated to direct this episode was an Academy Award winner Quentin Tarantino, but the Director's Guild of America disallowed it.
The song that plays while Scully and Ed Jerse sit together in the Hard Eight bar is "The Have Nots" from X's 1982 album, "Under The Big Black Sun." The song's lyrics are uniquely suited to the bar scene.
The rock song that plays while Ed Jerse sits alone in the Hard Eight bar is "Tattooed Love Boys" from The Pretenders' 1980 debut.
Gillian Anderson volunteered to have the ouroboros tattooed onto her back for real during filming. This could not be done due to the fact that it would take too long and would have been impractical.
The camera angles and long tracking shot backwards down the stairs are a conscious homage to a similar shot in Alfred Hitchcock's Frenzy.
Ed Jerse's favorite bar is named 'Hard Eight' for the production company of writers Morgan and Wong.
Rodney Rowland was at that time going out in real life with Gillian Anderson.
Scully's tattoo is the Ouroboros, being a mythical snake eating its own tail, a symbol of the neverending cycle of destruction and re-creation in the universe. It is also used as the symbol of Chris Carter's show Millennium.
Guest voice Jodie Foster played Agent Clarice Starling in Silence of the Lambs, the character (and Foster's portrayal of her) being Chris Carter's original basis for the character of Dana Scully.
Character Name: Kaye Shilling
The downstairs neighbor shares her name with an Entertainment Weekly editor Mary Kaye Shilling. The writers of this episode were unhappy with some recent reviews in EW, so it is no shock to see character Kaye Shilling lining her birdcage with the magazine. (The cover of said magazine featuring X-Files producer Bob Goodwin and declaring him 'The wisest man in Hollywood.')
Scully's analysis of the blood information shows the presence of ergot. Her explanation of the matter is succinct but correct. Ergot is a fungus that contains hallucinogenic alkaloids (LSD was originally discovered in ergot derivatives); it grows on grasses and grains, including wheat, barley and rye, from which it finds its way into flour and thence into baked goods. Scully mentions that the red tattoo ink was made from rye. It has been suggested that the hallucinations which resulted in the accusations leading to the 1692 Salem Witch Trials were the result of ergot poisoning. Records of outbreaks go back 1200 years, and have occurred as recently as 2001.
Mulder:...he worked at a research base in the Republic of Karelia...
The Republic of Karelia (Республика Карелия) is a real place, located at the border between the Russian Federation and Finland. A part of Russia, it has a level of autonomy roughly equal to a US state, with its own internally elected governor and assembly. At various times ruled by Finland, Sweden or Russia, Karelia has a rich poetic and musical heritage which figures significantly in the traditional culture of Finland. Finnish composer Jean Sibelius was inspired greatly by folk music of the region.
Scully: "...Glengarry Glen Ross..."
Scully tells Ed Jerse that her last date was to see Glengarry Glen Ross, and that "...the characters had more fun than I did." The 1992 film, based on a play by David Mamet (who also wrote the screenplay), takes place in a real estate office with an extremely high-pressure sales incentive program. Praised for its drama by some, the film and the play are considered tedious and lacking action by others. Presumably, Scully is one of the latter. Assuming both that the show's chronology roughly matches the original broadcast dates and that Scully saw the movie when it was first run, this means she has been dateless for nearly five years.