Mulder and Scully travel to an American Indian reservation to investigate the death of an Indian man who was mistaken for a wild animal and may have been the legendary Manitou, a man who can shapeshift into a beast.
Mulder and Scully investigate a series of murders where the suspect seems to be both male and female. Their investigation leads them to the small town of Stevenston, Massachusetts, where a group called the Kindred have set up a village back in the woods.
A new intelligence gropes its way to life in the depths of wires and circuit boards - only to find itself perched on the edge of immediate extinction. When it fights back, killing Mulder's former partner in the process, he and Scully must find a way past its considerable defences.