At the beginning of the episode, right before the agents meet Frank Black, they show the outside of Hartwell Psychiatric Hospital. The shot of the building shows that it is daytime. When they show Mulder and Scully walking down the hall, and speaking with Frank Black, it is very dark.
When Skinner hands Mulder and Scully the Millenium Groups symbol, we can see that it's a Ouroboros. This is the same symbol that Scully got tattooed on her back in Never Again.
The air date of this episode was November twenty-first, Chris Carter's wife's birthday.
When Mulder is laying on top of the operating table, we clearly see that he is strapped down to it. When Scully comes and they have that brief conversation he goes to hug her and is no longer strapped down.
Medical Reference: Phenytoin
Scully mentions that Mulder has been injected with phenytoin. Phenytoin is the generic form of the drug Dilantin. The most common use of this medication is the prevention of convulsions in seizure disorders such as epilepsy.
11:09 Mulder writes on Skinner's hand one way, but the next time it is shown it is different 14:43
When we see Scully writing down the translations of Navajo words for the nucleotides in DNA, adenine, guanine, thymine and cytosine, Scully has written the first one as "ademine".
When Mulder and Scully are examining the artifact in his office, there are pencils hanging from the ceiling tile over Mulder's desk in the background. Presumably this is a habit that Mulder has had at least since the episode, "Chinga," although they cannot be the same pencils since the office burned down at the end of season 5.
The establishing outside shot of the Hospital Mulder went to was also used that same year as San Francisco Memorial Hospital on the show Charmed. In this episode, the hospital is supposed to be in Georgetown.
Goof: Mulder's car is nowhere to be seen at the end when they are rescued.
When Scully approaches the area where Mulder's car was left, she is driving the coroner's pickup truck. And while the decal on the door of the truck clearly states Boone County Coroner, the truck has a US Government license plate on the front. In actuality it should have a county plate.
In one of the final scenes, Mulder discovers that they are still hallucinating, because their skins are unmarked even though they spent several days covered in digestive acids. Later, when they are really rescued from the acids, their skins still show little sign of being eaten at for several days.
In the scene just after the opening credits, Mulder is describing the Schiffs' bodies being found in the vicinity of Brown Mountain, NORTH Carolina; on the stand next to him is a giant map of SOUTH Carolina.
Not really a goof, but after Mulder shoots Skinner; Mulder strikes the James Bond pose.
Just before Scully makes the Y-incision on James (Jimmy) Belmont, you can see the pulse in his neck beating.
On the DVD the credits for this episode is incorrect. It lists the character of Grant Ellis as Grant Snow
There is a slight tip of the hand in the episodes' surprise -- the blood splattering forward onto Langly is an indicator that Susanne is using squibs -- real gunshot wounds don't splatter forward.
Goof: When Frohike plays the slot machine, the first position on the reel shows a single bar. After Byers spots Susanne, the camera goes back to Frohike and the first position now is not a single bar. There wouldn't have been enough time between the shots for Frohike to have another pull of the machine.
The baseball scenes in the episode were filmed at Jay Littleton Ballpark in Ontario, California.
The name of the Black baseball team at the beginning of the episode is the "Grays", an obvious reference to the alien nickname.
Also X's name is Josh, which references Josh Gibson who is the all time Negro-League Homerun King. Gibson played for the Homestead Grays.
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