Philip Rivers and the San Diego Chargers (6-7) travel to Sports Authority Field at Mile High in Denver to face Peyton Manning and the Denver Broncos (11-2).
Final Score: San Diego 27 Denver 20
Case Keenum and the Houston Texans (2-10), losers of a franchise record 10 in a row, travel to EverBank Field in Jacksonville to face Chad Henne and the Jacksonville Jaguars (3-9).
Final Score: Houston 20 Jacksonville 27
Drew Brees and the New Orleans Saints (8-2) travel to the Georgia Dome to face Matt Ryan and the Atlanta Falcons (2-9).
Final Score: New Orleans 17 Atlanta 13
Andrew Luck and the Indianapolis Colts (6-3) travel to LP Field in Nashville to face Ryan Fitzpatrick and the Tennessee Titans (4-5)
Final Score: Indianapolis 30 Tennessee 27
Robert Griffin III and the Washington Redskins (3-5) travel to Mall of America Field in Minneapolis to face Christian Ponder and the Minnesota Vikings (1-7).
Final Score: Washington 27 Minnesota 34
The Cincinnati Bengals (6-2) travel to Sun Life Stadium in Miami Gardens to face Ryan Tannehill and Miami Dolphins (3-4).
Final score: Cincinnati 20 Miami 22 (OT)
Cam Newton and the Carolina Panthers (3-3) travel to Raymond James Stadium in Tampa to face Mike Glennon and the Tampa Bay Buccaneers (0-6).
Final Score: Carolina 31 Tampa Bay 13
Russell Wilson and the Seattle Seahawks (5-1) travel to University of Phoenix Stadium in Glendale to face Carson Palmer and the Arizona Cardinals (3-3).
Final Score: Seattle 34 Arizona 22
Eli Manning and the New York Giants (0-5) travel to Soldier Field to face Jay Cutler and the Chicago Bears (3-2).
Final Score: New York 21 Chicago 27
In a game moved to 11:30 PM ET in order to avoid a conflict with the Oakland Athletics playoff game, Phillip Rivers and the San Diego Chargers (2-2) travel to O.co Coliseum to face Terrelle Pryor and the Oakland Raiders (1-3).
Final Score: San Diego 17 Oakland 27
E.J. Manuel and the Buffalo Bills (2-2) travel to FirstEnergy Stadium to face Brian Hoyer and the Cleveland Browns (2-2).
Final Score: Buffalo 24 Cleveland 37
Colin Kaepernick and the San Francisco 49ers (1-2) travel to Edward Jones Dome to face Sam Bradford and the St. Louis Rams (1-2).
Final Score: San Francisco 35 St. Louis 31
Alex Smith and the Kansas City Chiefs (2-0) travel to Lincoln Financial Field to face Michael Vick and the Philadelphia Eagles (1-1).
Final Score: Kansas City 26 Philadelphia 16
Rookie quarterback Geno Smith and the New York Jets (1-0) travel to Gillette Stadium in Foxborough, Massachusetts to face Tom Brady and the New England Patriots (1-0) in Thursday Night Football's eighth season debut.
Final Score: New York 10 New England 13