Tom and Manfred must race Crabby Appleton (the show's primary villain--he's "Rotten To The Core") to retrieve the Pill of Smartness, an artifact sitting on the hand of Cleopatra that makes whoever swallows it the smartest person in the world.
Tom gets mail from viewers of his cartoon show at the North Pole, who can get their local stations but not the network telecast from New York. Tom and Manfred go to the Empire State Building and rectify the transmitter's position.
The pirate Captain Kidney Bean and his crew plan on pillaging a nearby village. As Tom and Manfred infiltrate the pirate camp, Kidney Bean throws Tom off his ship and makes Tom think that Manfred is siding with the pirates.
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