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The pinky toe being an "evolutionary speed-bump" is mentioned in this episode. This was last mentioned by Teller at the start of season 1.
At the end of the episode you see the characters standing outside of the character "Beth's" house. The numbers on her house are 4252 which, if you add the first and last two digits together, equal 67.
67 was the number theme throughout this episode.
The Teller Institute is located at 318 West Tesla Street. Edward Teller was a Hungarian-American theoretical physicist, who was known as the father of the hydrogen bomb, and Nikola Tesla was a Serbian-American inventor, who developed the modern alternating current electrical supply system.