I can't see any show taking the place of this one with half the fun, If you really think about it and see what is out there there is no alternative! at all!
The real soul of this show always was Jon Cryer doing a fantastic job (and still is), along with a very inspired group of really talented writers and co-stars. This show couldn't be better. I was even surprised by the great performance of Ashton Kutcher that I confess was not high on my list of good actors, but that surprised me integrating himself so perfectly to the plot and showing his own talent. I am amazed by how critical people are of this show, when you think deeply it is one of the best shows ever and giving no signs of getting old!
This show always had sex undertones, and as always the soul of the show is Jon Cryer not Charlie Sheen, who now is in a crappy show of his own, those who do not like two and a half men must perhaps see the other one to gain some perspective!