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After being cured from the Goblin disease, Norman Osborn becomes the Iron Patriot. Suspicious that Norman isn't cured, Fury asks
Spider-Man to bring him in to S.H.E.I.L.D, but Spider-Man feels like Norman has changed and wants to give him a second chance. Harry still doesn't trust Spider-Man.
When Spider-Man and the team are attacked by Dracula and his vampire family, Blade and the Howling Commandos need to help defeat the blood-thirsty vampires.
When Arcade threatens the world with missiles, Captain America is sent in to stop him. Spider-man stows away on the plane and they join up with another hero.
On a mission with Shield agents, Power Man and Spider-Man discover that the two Shield scientists creating a super solider serum are Luke's long lost parents and need to rescue them.
When Nova's previous team comes to earth to enlist his assistance, Spider-man learns a new side to his undisciplined friend.
When Spider-man captures the Green Goblin and Shield imprisons him on the Heli-carrier, something is too easy about the capture. The ship is almost overrun with Venoms lead by a Goblin version and Dr. Octopus must help find a cure.
When Deadpool, a former teammate, returns to Shield to gather info on a villain, Spider-Man tags along with him on his mission to learn. Spidey learns that Deadpool is capable of going over the line.
Spiderman gets help defeating a villain from a most unlikely source, the janitor Stan Lee.
Spider-Man and the Hulk must deal with new problems when their minds are switched.
Spider-Man travels to K'un L'un when Iron Fist needs help and the Scorpion attempts to destroy them both.
The team is turned into mini-versions of themselves when they accidentally touch an Asgard relic.
When Spider-Man upgrades his spider tracers with tech from Tony Stark's lab, he accidentally creates a nearly unstoppable enemy.
The team travel to the moon to save J. Jonah Jameson's son and discover a menacing secret.
The team discover that Shield made a "few" upgrades to Aunt May's house and are trapped inside when Nova accidentally triggers the lock-down protocol.
When the Green Goblin returns to turn Spider-Man into a weapon, Carnage interferes by attacking both of them. This forces the two enemies into joining together to stop Carnage.
Six villains (five he knows and a new one) trap Spider-man alone.
When White Tiger starts acting strange and unfocused, the team tries to find out why and discovers that an enemy of White Tiger's father wants to take her powers.
Spider-Man must protect Flash Thompson from Rhino's attacks.
When Electro taps into and steals the city's power, Spidey and the team need to stop him.
Doctor Octopus is back and Spidey's attempts to stop him are hampered by Dr. Curt Connors' transformation into the Lizard.