When Stewie come out for his monologue he walks through a multi-colored curtain which is a reference to Johnny Carson who did the same.
This was the debut episode of Up Late with Stewie and Brian and aired at the same time as the 2007 Academy Awards.
D.L. Hughley and Michael Richards are announced as guests in the opening segment but do not appear on the show.
Notice Jesus is playing the drums but he goes by a different name.
I Love Lucy
When the show cuts to commercial, you can see Brian and Stewie in an I Love Lucy situation.