The team tries to track down their rogue member, and discover the artifact they have is unexpectedly powerful. Meanwhile, Claudia wonders about her future with the Warehouse team and Pete must choose between Kelly and the mission.
When Mrs. Frederic is stricken ill, the agents must search for a cure before it's too late. Their quest takes them to Egypt and the long-lost Warehouse 2.
Pete and Myka fall victim to an artifact that causes them to swap bodies, but the process will soon prove fatal if not reversed. Meanwhile, Artie and Claudia go after an artifact-enhanced seductress and Artie falls under her spell.
Myka takes Claudia on as a partner for the teenager's first full mission, investigating cases of spontaneous combustion among athletes. Meanwhile, Helena returns to plague the team.
Douglas Fargo, a member of Global Dynamics, travels from Eureka to Warehouse 13 to assist them with a computer system update. However, when a sentient computer virus is unleashed, the team is trapped when the warehouse goes into lockdown.
An artifact strikes close to home when the town near the Warehouse is plagued by an outbreak of B movie characters. Meanwhile, Mrs. Frederick and Valda undertake a risky procedure to discover what of MacPherson is still inside of Leena's mind.
After destroying the umbilicus, MacPherson rescues another prisoner from the Bronze Sector and travels to Europe for the next step in his plan. Pete and Myka identify the missing prisoner: H.G. Wells. Meanwhile, Mrs. Frederic determines the true traitor, and Claudia is briefly reunited with her brother.