From the beginning of this episode, Lisa is seen wearing the exactly same white outfit she was wearing when she was created for the very first time in the first episode of the series. This will make a lot of sense later in the episode as she has to be "recreated" like the very first time.
Lisa: I just had a terrible thought.
Wyatt: Please share.
Lisa: If you never existed, then you weren't around to help Gary create me.
Wyatt: What are you saying?
Lisa: Stupid old me. I zappped the both of us right out of existence. Are you mad?
In this episode, Melanie Chartoff takes over the role of Marcia Donnelly.
In the alternate world, Lisa's first line after being created is "What do you little maniacs want to do first?" This was Lisa's first line in the original Weird Science movie.
The title of this episode, of course, references the famous Capra movie It's a Wonderful Life.