This is the first time we see a reference to Grace wanting to have a kid with Will, which is a major storyline in season 4.
Foreshadowing: Jack makes reference to donating sperm, which eventually leads to his discovery of Elliot at the end of Season 3.
The Nurse is continuously credited as "Sheila" throughout the rest of the series, yet in this episode when she shows Will his "room" her nametag clearly says "Sue"
Jack: Last night, when Mitch and I were celebrating our half-week-aversary, um... Stan caught us doing a little somethin'-somethin' on his Viking oven.
Will: Ooh, sort of... homo on the range.
Jack: Karen, take me to your dentist. I feel my teeth are dull and people are laughing at me.
Grace: Oh, Jack, that's not why people are laughing.
Claire: I'm guessing you're a high-maintenance kind of friend.
Jack: I cost a little more, but I'm worth it.
Grace: What is with friends showing up 15 years later asking for sperm? I don't know about you, but I never wrote in anyone's yearbook, "Don't ever change and please fill this cup."
(Looking at the magazines)
Will Booties, Jugs and Cans. Oh my.
Karen: Ok. First of all the shoes go back on the Mayflower.
Karen: (tugging on Grace's right pig tail) By the look of this hair, I think this little piggie should stay home.
Grace: Karen, what are you doing here? You calling in sick this morning.
Karen: ... (Half-Assed Cough)
Will: (To Grace) You selfish lunatic, get out of my spermatorium.
Karen: Honey, what's with this place? You're a lawyer. Why are you living in the projects?
Will: I like to be close to my homeys and Zabar's. They make a smoked sable that is da bomb.
Karen: By your inflection, I can tell that you think what you're saying is funny, but ... no. (To Jack) Come on, poodle, let's go.
Will: (looking at magazines at the sperm donation center) Booties and Jugs and Cans. Oh my.
This is a twisted take on the line, "Lions and tigers and bears...oh my!" from The Wizard Of Oz.
Will: Decorator, unpack thyself!
This is a play on words from the biblical phrase "Physician, heal thyself" from the Gospel according to Luke.
Jack: You can't just start sleeping with women. Who are you, Anne Heche?
It's rumored that Anne Heche, who'd never been with a woman before she started dating Ellen DeGeneres, did so for the publicity.
Will: Claire, this is Charlie Brown's French teacher.
The teacher's voice on The Charlie Brown and Snoopy Show was nothing more than the sound of a trumpet with a plunger head on the horn.
Will: Yeah. What's that about, Pippi?
Quick reference to the cartoon series and later movie Pippi Longstocking.