James Burrows directed every episode of the series, including the pilot and the series finale.
Karen made a joke about knowing Marlo Thomas, which is a running joke which began in the season 1 episode, "The Truth About Will And Dogs".
Allusions to previous episodes: The scene at the end with Will and Grace on the phone is intentionally reminiscent of the opening scene of the pilot, including a reference to ER and George Clooney.
The final scene is held at what appears to be the same bar in "The Pilot (Love and Marriage)" where everyone thought Will & Grace had just been married and got them to kiss each other.
Jack and Karen touch tummies just like they did when they first met in the season 1 episode "A New Lease On Life".
Eric McCormack (Will), Sean Hayes (Jack), and Megan Mullally (Karen) appeared in every episode of Will & Grace. Debra Messing (Grace) was absent from a few season six episodes when she was pregnant.
The final song played at the end is "You're My Best Friend" by Queen.
This episode was Entertainment Weekly's Pick of the Week.
Warren: I'm going over to Sandoval's.
Steve Sandoval is a producer for the show.
Hospital page: Dr. Kohan... extension 456... Dr. Kohan extension 456.
David Kohan is one of the show's creators.
This is Tina's first appearance since the season 6 episode "I Never Cheered for my Father". This episode also marks her final appearance in the series. Additionally, this episode marks the final appearances of Marilyn Truman, Joe & Larry, and Rob & Ellen.
In "A Little Christmas Queer", Steven Weber was listed as a "Guest star", and in this episode, as a "Special guest star".
"Blanket Apology" marks the final appearances of Eileen Brennan and Sydney Pollack.
This is George's first appearance since the season 4 episode "Cheatin Trouble Blues".
This is Zandra's first appearance since the season 6 episode "Flip-Flop (2)".
Will's father suffers a heart attack and passes away.
Continuity Goof: Rosario said that she had a trust fund worth 2 million dollars (the money Stan left her), but in Stan's will, he left her 10 million dollars.
In the episode, Amber-Louise mentions violations of civil rights and interment camps; in real life, guest co-star George Takei has spend some time during WWII in a detention camp set up by the United States following the start of hostilities with Japan.
Will insists that he was not a Trekkie. Meanwhile Eric McCormack (Will) starred alongside William Shatner as a hardcore Trekkie in the 1998 movie Free Enterprise as well as the 2006 sequel.
Continuity Goof: Will says in this episode that he doesn't like cowboys and doesn't find them sexy. However, in the Season 1 episode, "Will on Ice", Will expresses how he wants to have a "Real Cowboy" for his next birthday and Grace expresses how he has Cowboy magazines.
This is the first episode that Beverley Leslie has appeared in scenes without Karen.
When Pam says it's better to pray from an east facing wall she referes to the Jewish way of praying, facing Jerusalem, which in America means east.