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An ancient and immensely powerful mutant, known as Apocalypse, creates four Horsemen to help usher in a new world where survival of the fittest reigns.
The X-Men return from Genosha, finding the home destroyed, and Professor Xavier missing. They suspect a super-strong Russian mutant named Colossus, but the real culprit turns out to be someone more human, far tougher, and with deeper ties to the Professor.
Rogue seeks a scientist who claims to be able to "cure" any mutant of their powers, unaware that neither he, nor his process, are what they appear to be.