I rate You Again as the worst sitcom of the 80's. It ranks with Me and the Chimp, My Mother the Car, and the Brian Benben Show as the worst TV sitcoms of all time. What makes You Again unique from all these other clunkers is that it somehow managed to get renewed for a second season after debuting as a replacement series in February of 1986. Mercifully for us viewers, it didn't last any longer than half of another season before NBC pulled the long overdue plug.
One wonders what Jack Klugman was thinking when he signed on for this drivel. Maybe he had a lot of gambling debts and simply needed the money to pay off his bookie. As for John Stamos, he'd just come from a stint on General Hospital where he showed no talent whatsoever and he'd go onto a long stint on Full House where he'd again show no talent whatsoever. At least You Again didn't stop Stamos from getting work although that's not really a good thing in my opinion.
Flush You Again down the sewer where it belongs.