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Unity's fate has been decided, it will be turned into a hotel/casino facility. Tempers flare among the crew as they contemplate their uncertain futures.
The future of Unity station looks bleak, due to a soon-to-be launched new space platform, named Hyperion.
Earth is devastated after a nuclear explosion causing a deadly disease break-out. The crew of Unity begin to experience friction among themselves as a result.
It is the Unity's fifteenth anniversary, and the crew are given a day off to celebrate.
Silver Bullet, a project that gives hope for a cure to leukemia. The project is placed in danger, primarily due to Harry's cat and a hybrid plant.
Walter, Kaveh, Paula and Dusan discover an orphan, Orla, aboard an abandoned space platform.
The world's last live specimen of the smallpox virus is being transferred to Unity for "safe" keeping. Lyle has an crisis of ethics on whether to let such a deadly thing survive. Meanwhile the crew begin to fall ill and it seems their worst fears have come to life.
CALUM is brought to Unity by Professor Jarvis to replace the station's mainframe. In control of the station, CALUM suddenly becomes sentient. Just as quickly, however, it begins to break down, jeopardizing the safety of the station.
A shuttle hit by a meteor crashes into Unity. While crew of Unity have the grim job of recovering the corpses and their personal effects from the shuttle, strange and unexplained events begin happening around the space station.
Solar flares are casing havoc aboard Unity. A cargo freighter docks with Unity and has two stowaways aboard.
Harry and Lyle come to terms with the new hierarchy in the science section. Meanwhile, the lives of the Unity crew are put in danger.
Harry returns to the station around ten months after her departure with her baby, Miranda.
The arrival of a maintenace shuttle brings an unexpected visitor, Anderson from the failed Clementine mission. Commander McTiernan is concerned as the details surrounding Anderson's mission are vague and his shuttle is registered to a nonexistent company.