Stewie claims that "Ring Around the Rosie" is a song in reference to the Bubonic Plague. This is a widely held misconception.
Stewie: (pretending to be a woman to Brian) You have no idea how long it's been since I've been touched by a man.
Brian: And you have no idea how long it's been since I've been touched by a woman. (long pause, Brian guides Stewie's hand under the table)
Stewie: Brian-Bri-BRIAN! It's me it's Stewie!
Brian: (outraged slams Stewie against the seat) WHAT THE F**K IS WRONG WITH YOU?!?
Meg: You kissed my boyfriend! How are we supposed to get past that?
Lois: I don't know, sweetheart, but I am so, so sorry. It was an awful thing that I did; I never meant to steal him from you.
Meg: (incredulous Is that what you think? You stole him from me? Are you kidding? You couldn't steal him from me.
Lois: (a little amused) Well, I do know a few things, Meg, and clearly if I wanted him I could have him.
Meg: You really think you stand a chance? Look at you! You're old! You're nothing! You couldn't even imagine the things I do for him. And this isn't about making out. This is about power tools. I do things for him that you couldn't get back from. I'll do anything! You don't know me! (pulls out one of her own teeth)
Lois: Oh my god!
Meg: (throws the tooth at Lois) He hangs me from the shower rod by your old bras and then we laugh at you. Now get out of my room!
Lois: (backs away and speaks in a placating tone) Well, when you're ready to talk...
Randall: Quiet on the set! I'm trying to rehearse!
Julie: It's okay. Randall's just getting into character.
Stewie: (as Karina) Is he playing a dick?
Peter: Lois, I don't mind you getting old, just don't force it down my throat.
Lois: Screw yuo, Peter.
Peter: Maybe you will, but not today! (laughs)
The music that plays after Lois says, "Rape?" is the music from the opening credits of Seinfeld.
One of the scenes shown of Jolly Farm is an allusion to Sesame Street.
Stewie dressing as a girl to get a role in a tv show, as well as lines and music from the episode, are a reference to the 1982 movie Tootsie.