This episode has a lot of references to previous episodes and events within the show's history:
Reference is made to the Season 1 episode Antonia Ramos when Sean mentions that the titular character was a drug-mule of Escobar's whose breasts got infected by the drug-filled implants.
There are several references to the Pilot episode, with Christian mentioning getting 'a Botox shot in the dick' from Escobar (and the eventual disposal of both Silvio Perez and, later, Escobar himself).
Sean mentions Escobar shooting Liz, which happened in the Season 1 finale Escobar Gallardo and also mentions the murder of Alejandro Perez in his living room (which happened in Merrill Bobolit).
Michelle and Christian talk about the stealing of Liz's kidney (in Shari Noble).
In the final scene, the intern mentions 'the Rosenberg case' (Sean and Christian separated a pair of conjoined twins in the Season 2 episode Rose And Raven Rosenberg) and Sean's 'son's ectrodactyly operation' (in Conor McNamara)